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Zhang Baoyin Mo Zeyao Wang Xin Wang Wei Li Gang Zhang Aiqing Cao Xiaolin 《The Journal of supercomputing》2021,77(10):11270-11287
The Journal of Supercomputing - Domain-specific programming frameworks are usually effective to simplify the development of large-scale applications on supercomputers. This paper introduces a... 相似文献
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Delf-Magnus Kummerfeld Carsten A. Raabe Juergen Brosius Dingding Mo Boris V. Skryabin Timofey S. Rozhdestvensky 《International journal of molecular sciences》2021,22(7)
Prader-Willi syndrome (PWS) is a neurogenetic multifactorial disorder caused by the deletion or inactivation of paternally imprinted genes on human chromosome 15q11-q13. The affected homologous locus is on mouse chromosome 7C. The positional conservation and organization of genes including the imprinting pattern between mice and men implies similar physiological functions of this locus. Therefore, considerable efforts to recreate the pathogenesis of PWS have been accomplished in mouse models. We provide a summary of different mouse models that were generated for the analysis of PWS and discuss their impact on our current understanding of corresponding genes, their putative functions and the pathogenesis of PWS. Murine models of PWS unveiled the contribution of each affected gene to this multi-facetted disease, and also enabled the establishment of the minimal critical genomic region (PWScr) responsible for core symptoms, highlighting the importance of non-protein coding genes in the PWS locus. Although the underlying disease-causing mechanisms of PWS remain widely unresolved and existing mouse models do not fully capture the entire spectrum of the human PWS disorder, continuous improvements of genetically engineered mouse models have proven to be very powerful and valuable tools in PWS research. 相似文献
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由于Kutta-Joukowski横向力与浓度梯度力的共同作用,提升管内颗粒沿径向在边壁大量聚集并形成稳定的环?核结构。根据实验数据,分析了颗粒浓度梯度的径向分布特征,考察了不同操作条件下浓度梯度力系数K的分布特性。由Kutta-Joukowski横向力与浓度梯度的关系,提出了浓度梯度力的表达式Fρ=K(dρ/dr)A及浓度梯度力系数K的表达式K=[?ρg(νg?νp)(?v/?r)r]/?dρ/dr+(d2ρ/dr2)r?。提升管内颗粒群受到的浓度梯度力与浓度梯度力系数K有关。浓度梯度力系数K在提升管中心处为0,沿提升管径向呈“N”型分布,随表观气速增加而增加;提升管内充分发展段K的数值明显大于提升管加速区和出口约束区,总结了浓度梯度力系数K的经验关联式。 相似文献
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Zhao-Hua Mo Rui Yang Song Hong Yi-Xian Wu 《International Journal of Hydrogen Energy》2018,43(3):1790-1804
Introducing graphene into polymer matrix is an effective way to enhance performances of anion exchange membrane (AEM). However, utilizing the advantages of graphene by physical approach is limited due to the weak interface interaction between graphene and polymer matrix. Herein, we report an effective strategy to covalently bond graphene with polymer matrix to improve the interface interaction and further to improve the properties of AEM. A series of cross-linked quaternized graphene-based hybrid AEM were fabricated by covalently bonding poly (vinylbenzyl chloride) grafted graphene (GN-g-PVBC) copolymer with chloromethyl functionalized poly (styrene-b-isobutylene-b-styrene) (SIBS) through the cross-linker (N,N,N′,N′-tetramethyl-1,6-hexanediamine) by in-situ synthetic approach. The interface interaction between graphene and QSIBS is greatly enhanced according to micromorphology characterization of the hybrid membrane. The cross-linked quaternized hybrid AEM containing 0.55 wt% of GN-g-PVBC exhibits obviously improved dynamical mechanical properties (storage modulus: 418 MPa), ion conductivity (1.81 × 102 S cm?1), methanol barrier property (5.19 × 10?7 cm2 s?1), selectivity (3.49 × 104 S s cm?3) at 60 °C and especially a comparably excellent chemical stability to that of Nafion 115 due to the enhanced interface interaction between graphene and the polymer matrix. 相似文献
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Moškon Miha Komac Roman Zimic Nikolaj Mraz Miha 《Neural computing & applications》2021,33(15):8923-8938
Neural Computing and Applications - Ever since its foundational years, synthetic biology has been focused on the implementation of biological computing structures. In the beginning, engineered... 相似文献
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Jiadong Liu Di Yu Zhipeng Zheng Geng Huangfu Yiping Guo 《Ceramics International》2021,47(3):3573-3579
Constructing hybrid nanogenerators (NGs) based on triboelectric effect and piezoelectric effect can combine the merits of the individual type of NG thus have drawn great attention in flexible wearable electronics. Herein, we prepared flexible BiFeO3 (BFO) film in a simple and cost-effective way, which was used to fabricate a wearable hybrid piezoelectric-triboelectric nanogenerator (H–P/TENG) with silk fiber. By optimizing the experimental conditions, the highest open-circuit voltage of 110 V and short-circuit current density of 3.67 μA/cm2 were achieved under 1 Hz contact-separation movement. The device also showed the best output power density of 151.42 μW/cm2 with load resistance of 250 MΩ. Stimulating by moving body, the fabricated H–P/TENG successively realized the harvest and conversion of mechanical energy into electric energy, demonstrating great potential to monitor posture and establish a self-powered system. Moreover, the proposed H–P/TENG exhibited great stable output after 1800 contact-separation cycles, indicating the outstanding structure stability and fatigue resistance. This work will provide not only a facile and viable way to realize the application of ferroelectric materials in H–P/TENG but also new opportunities for developing monitor posture and self-powered systems. 相似文献
10.
Liang Yong-chao Ma Rui-bo Zhou Li-li He Mu Tian Ze-an Mo Yun-fei 《Journal of Superconductivity and Novel Magnetism》2021,34(12):3377-3383
Journal of Superconductivity and Novel Magnetism - A molecular dynamics simulation has been conducted in Ni73Co27 and Ni74Co26 alloys during rapid solidification at the cooling rate of... 相似文献